Comparison of Ambulatory Blood Pressure Parameters of Hypertensive Patients With and Without Chronic Kidney Disease
Key result
Chronic kidney disease in hypertensive patients was associated with a significantly higher prevalence of non-dipping (60.6% vs 43.2%; P<0.001) and riser blood pressure patterns.
Why the study?
Does the presence of chronic kidney disease increase the prevalence of abnormal circadian blood pressure patterns in hypertensive patients?
Population
10,271 hypertensive patients, mean age 58.0 ± 14.2 years, enrolled in the Hygia Project. 3,227 had chronic…
Design
Cross-sectional
Authors
Discussion
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Implication
Hypertensive CKD patients may need closer nocturnal BP monitoring; leaves open whether ABPM improves outcomes in prospective studies.
Study Design
Type
Cross-Sectional (n=10,271)
Structured PICO
Does the presence of chronic kidney disease increase the prevalence of abnormal circadian blood pressure patterns in hypertensive patients?
P
Population
10,271 hypertensive patients (mean age 58.0 years, 46.4% female), including 3,227 with chronic kidney disease, assessed by 48-h ambulatory blood pressure monitoring.
C
Comparator
Hypertensive patients without chronic kidney disease (CKD)
O
Outcome
Circadian blood pressure pattern (non-dipping and riser BP patterns) assessed by 48-h ambulatory blood pressure monitoring (ABPM)surrogate
Main Result
Absolute Event Rate: 60.6% vs 43.2%
p-value: p=<0.001
Hypertensive patients with chronic kidney disease have a significantly higher prevalence of blunted nocturnal blood pressure decline and riser BP patterns, supporting the mandatory use of ABPM for cardiovascular risk assessment in this population.
Cite This Study
Mojón et al. (2012) conducted a cross-sectional in Hypertension with and without chronic kidney disease (n=10,271). Chronic kidney disease vs. Without chronic kidney disease was evaluated on Prevalence of non-dipping blood pressure pattern (p=<0.001). Chronic kidney disease in hypertensive patients was associated with a significantly higher prevalence of non-dipping (60.6% vs 43.2%; P<0.001) and riser blood pressure patterns.