Key result
Bedtime administration of antihypertensive medications restores normal physiologic blood pressure reduction during sleep and decreases cardiovascular risk in patients with chronic kidney disease.
Why the study?
Does bedtime administration of antihypertensive medications reduce cardiovascular and cerebrovascular risk in patients with chronic kidney disease?
Population
Patients with chronic kidney disease (CKD) and hypertension
Design
Review
Authors
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May support bedtime dosing to restore dipping in CKD; leaves open prospective RCTs for CV outcome confirmation.
Does bedtime administration of antihypertensive medications reduce cardiovascular and cerebrovascular risk in patients with chronic kidney disease?
Ambulatory blood pressure monitoring and bedtime dosing of antihypertensive medications are recommended to restore normal night-time blood pressure dipping and reduce cardiovascular risk in patients with chronic kidney disease.
Hermida et al. (2013) conducted a review in Chronic kidney disease and hypertension. Bedtime hypertension chronotherapy was evaluated. Bedtime administration of antihypertensive medications restores normal physiologic blood pressure reduction during sleep and decreases cardiovascular risk in patients with chronic kidney disease.
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