Key result
Novel risk factors such as endothelial dysfunction and vascular calcification play a more important role for vascular disease in CKD and ESRD patients compared to the general population.
This review highlights the importance of both traditional and novel risk factors for coronary artery disease in patients with chronic kidney disease and end-stage renal disease.
May inform vascular risk assessment in CKD/ESRD; leaves open whether targeting endothelial dysfunction or calcification improves outcomes.
Cardiovascular diseases are the most common cause of mortality and morbidity in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) receiving hemodialysis and peritoneal dialysis. Beside traditional risk factors including hypertension, diabetes, dyslipidemia, advanced age novel risk factors such as endothelial dysfunction, hyperphosphatemia, hyperparathyroidism, vascular calcification, increased oxidative stress and inflammation are highly prevalent and seem to play a more important role for vascular disease in CKD and ESRD patients compared to general population. This review briefly discuss classical and recent epidemiologic, pathophysiologic and clinical aspects of coronary artery disease in ESRD patients.
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Türkmen et al. (2013) conducted a review in Coronary artery disease in chronic kidney disease and end-stage renal disease. Cardiovascular risk factors vs. General population was evaluated. Novel risk factors such as endothelial dysfunction and vascular calcification play a more important role for vascular disease in CKD and ESRD patients compared to the general population.
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