Key result
This review discusses the role of RNA interference as a defensive strategy in mammalian host cells and the mechanisms of viral silencing suppressors.
This review discusses the role of RNA interference as an innate immune defense in mammalian cells and the mechanisms by which viral silencing suppressors counteract this pathway.
May guide antiviral strategies targeting RNAi suppressors; leaves open clinical translation pending further validation.
RNA silencing is a conserved eukaryotic pathway involved in the suppression of gene expression via sequence-specific interactions that are mediated by 21-23 nt RNA molecules. During infection, RNAi can act as an innate immune system to defend against viruses. As a counter-defensive strategy, silencing suppressors are encoded by viruses to inhibit various stages of the silencing process. These suppressors are diverse in sequence and structure and act via different mechanisms. In this review, we discuss whether RNAi is a defensive strategy in mammalian host cells and whether silencing suppressors can be encoded by mammalian viruses. We also review the modes of action proposed for some silencing suppressors.
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Song et al. (2011) conducted a review in Viral infection. This review discusses the role of RNA interference as a defensive strategy in mammalian host cells and the mechanisms of viral silencing suppressors.
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