During the last several years many studies have attempted to describe the action of vasoactive substances on the pulmonary vascular bed, to charac terize the humoral receptors of its smooth muscle receptors, and to deter mine the make-up of the cascades of activation and release of agents that may mediate the pulmonary vascular responses to their major regulators, i.e. the levels of O2 and CO2,
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Edward H. Bergofsky (1980) studied this question.
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