Population
293T and Cos-1 cells transfected with HIV-1 proviral clones
Comparison
HIV-1 M1-2/BR mutant virus vs Wild-type HIV-1 provirus (pHXB2gpt)
Design
Preclinical
Authors
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Gag-RNA binding supports post-assembly particle integrity beyond initial interactions; hypothesis-generating in this animal model and leaves open translation to higher systems.
RNA binding by Gag is critical to retroviral particle integrity after cell membrane assembly, rather than just for Gag-Gag interactions during assembly.
Wang et al. (2002) studied this question.
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