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July 1, 1986Journal of VirologyOpen Access

A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging

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Population

Avian sarcoma virus DNA clone transfected into chicken embryo fibroblasts

Design

Preclinical

Authors

RKRichard A. KatzFox Chase Cancer CenterRTRobert W. TerryLa Roche CollegeASA M SkalkaUtah State University

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Implication

Identifies essential cis-acting packaging signal in avian sarcoma virus; leaves open conservation and function in human retroviruses.

Structured PICO

P
Population
Avian sarcoma virus DNA clone transfected into chicken embryo fibroblasts
I
Intervention
Deletion of a conserved sequence of ca. 30 nucleotides in the 5' noncoding leader region
O
Outcome
Viral infectivity and amount of mutant viral RNA encapsidated into virionssurrogate

Identifies a conserved 30-nucleotide sequence in the 5' leader of avian sarcoma virus RNA as an essential cis-acting packaging signal.

Cite This Study

Katz et al. (1986) studied this question.

synapsesocial.com/papers/6a901fd8b71d06dae589d5e9https://doi.org/10.1128/jvi.59.1.163-167.1986
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs1985 · 164 citations
  2. 2Messenger Activity of Virion RNA for Avian Leukosis Viral Envelope Glycoprotein1979 · 22 citations
  3. 3cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus1983 · 115 citations
  4. 4The leader sequence of the subgenomic mRNA's of Rous sarcoma virus is approximately 390 nucleotides1982 · 74 citations
  5. 5Characterization of a Rous sarcoma virus mutant defective in packaging its own genomic RNA: biological properties of mutant TK15 and mutant-induced transformants1984 · 79 citations