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December 1, 1996Journal of VirologyOpen Access

A dual role of the putative RNA dimerization initiation site of human immunodeficiency virus type 1 in genomic RNA packaging and proviral DNA synthesis

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Population

Four mutant human immunodeficiency virus type 1 (HIV-1) viruses

Comparison

Deletion or substitution of the stem-loop… vs Wild-type HIV-1

Design

Preclinical

Authors

JPJean‐Christophe PaillartCentre National de la Recherche ScientifiqueLBLionel BerthouxUniversité du Québec à Trois-RivièresMOMichèle OttmannUniversité Claude Bernard Lyon 1

Discussion

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Implication

Stem-loop critical for HIV replication in animal models; leaves open its viability as antiviral target pending human validation.

Structured PICO

P
Population
Four mutant human immunodeficiency virus type 1 (HIV-1) viruses
I
Intervention
Deletion or substitution of the stem-loop structure (dimerization initiation site) in the 5' leader of HIV-1 RNA
C
Comparator
Wild-type HIV-1
O
Outcome
Virion formation, infectivity, genomic RNA packaging, and proviral DNA synthesissurrogate

The stem-loop structure known as the dimerization initiation site in HIV-1 is a cis element crucial for both genomic RNA packaging and proviral DNA synthesis.

Cite This Study

Paillart et al. (1996) studied this question.

synapsesocial.com/papers/6a9020cc263a63a56f89c969https://doi.org/10.1128/jvi.70.12.8348-8354.1996
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mode of dimerization of HIV-1 genomic RNA1993 · 106 citations
  2. 2A 19-Nucleotide Sequence Upstream of the 5' Major Splice Donor Is Part of the Dimerization Domain of Human Immunodeficiency Virus 1 Genomic RNA1994 · 235 citations
  3. 3Structure of B77 sarcoma virus RNA: stabilization of RNA after packaging1975 · 87 citations
  4. 4A loop-loop "kissing" complex is the essential part of the dimer linkage of genomic HIV-1 RNA.1996 · 273 citations
  5. 55′ Regions of HIV-1 RNAs Are Not Sufficient for Encapsidation: Implications for the HIV-1 Packaging Signal1995 · 78 citations