Key result
Intra-operative use of hypertonic saline solutions during surgeries was associated with reduced positive fluid balance, increased cardiac index, and decreased systemic vascular resistance.
Why the study?
Does the intra-operative use of hypertonic saline solutions improve hemodynamic parameters in patients undergoing surgery?
Does the intra-operative use of hypertonic saline solutions improve hemodynamic parameters in patients undergoing surgery?
Intra-operative use of hypertonic saline solutions during cardiac and other surgeries may improve hemodynamic parameters, though well-designed clinical trials are needed.
May support intra-operative fluid management; leaves open confirmation of benefits by randomized trials.
Hyperosmotic-hyperoncotic solutions have been widely used during prehospital care of trauma patients and have shown positive hemodynamic effects. Recently, there has been a growing interest in intra-operative use of hypertonic solutions. We reviewed 30 clinical studies on the use of hypertonic saline solutions during surgeries, with the majority being cardiac surgeries. Reduced positive fluid balance, increased cardiac index, and decreased systemic vascular resistance were the main beneficial effects of using hypertonic solutions in this population. Well-designed clinical trials are highly needed, particularly in aortic aneurysm repair surgeries, where hypertonic solutions have shown many beneficial effects. Examining the immunomodulatory effects of hypertonic solutions should also be a priority in future studies.
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Azoubel et al. (2008) conducted a review in Surgeries (predominantly cardiac). Hypertonic saline solutions was evaluated on Hemodynamic effects (fluid balance, cardiac index, systemic vascular resistance). Intra-operative use of hypertonic saline solutions during surgeries was associated with reduced positive fluid balance, increased cardiac index, and decreased systemic vascular resistance.
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