The separation of enantiomers of underivatized ketoprofen, as well as a number of other non-steroidal anti-inflammatory drugs, was studied by high performance liquid chromatography using a recently developed chiral stationary phase packed in a microbore column. Electrostatic and π-π interactions are assumed to control the retention of the analytes. The enantioselectivity remains constant in a wide range of organic modifier concentration, and is restricted to a pH window ranging from 2.5 to 5.0.
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Castellani et al. (1994) studied this question.
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