Key result
The addition of 2% sevoflurane to 0.8 mg/kg rocuronium significantly reduced the onset time of intubation compared to rocuronium alone (59.6 vs 102.65 seconds, P < 0.001) in neurosurgical patients.
Why the study?
Rocuronium provides good intubating conditions, but large doses prolong its duration of action, making it unsuitable for short surgical procedures.
Does adding 2% sevoflurane to rocuronium reduce the onset time for intubation in adult patients undergoing lumbar disc operations?
RCT (n=40)
Double-blind
Randomly allocated
No
Does adding 2% sevoflurane to rocuronium reduce the onset time for intubation in adult patients undergoing lumbar disc operations?
Absolute Event Rate: 59.6% vs 102.65%
p-value: p=<0.001
The addition of 2% sevoflurane to rocuronium 0.8 mg/kg significantly reduces the onset time of intubation and provides rapid sequence intubation in neurosurgical patients.
May expedite intubation in neurosurgical patients; leaves open whether outcomes improve in larger trials.
Background: Rocuronium provides good intubating conditions but large doses causes prolongation of its duration of action, making it unsuitable for short surgical procedures. Aims: We assessed the efficacy of sevoflurane with rocuronium during induction in terms of reducing the onset time for intubation, evaluating intubating conditions and haemodynamic responses during intubation.Subjects and Methods:This prospective, randomised, double-blind study was conducted in 40 adult patients undergoing lumbar disc operations under general anaesthesia were randomly allocated into two equal groups namely Group R (received 0.8 mg/kg of rocuronium) and Group RS (received 0.8 mg/kg of rocuronium and 2% sevoflurane during induction).Results:The two groups were comparable with respect to age, sex, weight and ASA grade. The time for loss of thumb adduction was 101.4 ± 11.2 s in Group R compared with 61.04 ± 5.4 s in Group RS P < 0.001]. The onset time of intubation was significant P < 0.001]. Significant differences in heart rate and mean arterial pressure were seen immediately after intubation, at 1 and 3 min after intubation (P < 0.05) between the two groups. The mean intubation score was comparable in both the groups is insignificant[P = 0.11].Conclusion:Rocuronium 0.8 mg/kg along with 2% sevoflurane provides rapid sequence intubation during anaesthesia in neurosurgical patients.
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Cherayath et al. (2020) conducted an RCT in Lumbar disc operations under general anaesthesia (n=40). Rocuronium with Sevoflurane vs. Rocuronium 0.8 mg/kg alone was evaluated on Onset time of intubation (p=<0.001). The addition of 2% sevoflurane to 0.8 mg/kg rocuronium significantly reduced the onset time of intubation compared to rocuronium alone (59.6 vs 102.65 seconds, P < 0.001) in neurosurgical patients.
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