This is the authors' abstract. We don't add key points for this paper.
A copper‐catalyzed oxidative C(sp3)−H/N−H coupling of NH‐heterocycles with affordable (cyclo)alkanes has been developed. This procedure involves C(sp3)−N bond formation through a radical pathway generated by homolytic cleavage of di‐tert‐butyl peroxide and trapping of the radical(s) by copper catalysts. The reaction tolerates a series of functional groups, such as bromo, fluoro, ester, ketone, nitrile, methyl, and methoxy. free‐NH‐containing indoles, pyrroles, pyrazoles, indazoles, and benzotriazoles are successfully N‐alkylated.
Answers are grounded in this paper and cite their sources.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: