What question did this study set out to answer?

To evaluate the efficacy and molecular mechanisms of dietary blueberries in reducing pro-inflammatory cytokine production in mouse macrophages.

September 2, 2011Molecular Nutrition & Food Research

Blueberries reduce pro‐inflammatory cytokine TNF‐α and IL‐6 production in mouse macrophages by inhibiting NF‐κB activation and the MAPK pathway

View Full Paper

Ask AI

Bookmark

Authors

CXCheng‐Hui XieMinistry of Agriculture JKJie KangChinese Academy of Medical Sciences & Peking Union Medical College MFMatthew FergusonEmory University

Discussion

Member takes

Implication

Controlled animal study demonstrates reduced cytokine production in mouse macrophages via blueberry supplementation, suggesting a molecular mechanism for attenuating atherosclerosis.

Key Points

To evaluate the efficacy and molecular mechanisms of dietary blueberries in reducing pro-inflammatory cytokine production in mouse macrophages.
Fed ApoE(-/-) mice a control diet or a diet containing 1% freeze-dried blueberries for 5 weeks, measuring cytokine levels in serum, aorta, and peritoneal macrophages under basal, LPS-, or oxLDL-stimulated conditions.
Treated RAW264.7 macrophages with polyphenol-enriched serum extracts from rats fed control diet or 10% blueberry diet to assess intracellular signaling pathways.
Blueberry supplementation significantly decreased serum levels of TNF-α and IL-6, down-regulated aortic TNF-α expression, and reduced cytokine protein and mRNA levels in peritoneal macrophages.
Blueberry-enriched serum extract suppressed LPS-induced TNF-α and IL-6 production and inhibited the phosphorylation of IκB, NF-κB p65, p38 MAPK, and JNK in RAW264.7 cells.

Cite This Study

Xie et al. (2011) studied this question.

synapsesocial.com/papers/6a9021882e3cec13db33ca82 https://doi.org/10.1002/mnfr.201100344

View Full Paper

Ask AI

Bookmark

Implication

Controlled animal study demonstrates reduced cytokine production in mouse macrophages via blueberry supplementation, suggesting a molecular mechanism for attenuating atherosclerosis.

Blueberries reduce pro‐inflammatory cytokine TNF‐α and IL‐6 production in mouse macrophages by inhibiting NF‐κB activation and the MAPK pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Blueberries reduce pro‐inflammatory cytokine TNF‐α and IL‐6 production in mouse macrophages by inhibiting NF‐κB activation and the MAPK pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider