Key result
Sevoflurane lengthened the QTc and QTVI intervals similarly in both children with congenital sensorineural hearing loss and controls, with no differences between the groups.
Why the study?
Does sevoflurane differentially affect QT parameters in children with congenital sensorineural hearing loss compared to controls?
Observational (n=60)
Does sevoflurane differentially affect QT parameters in children with congenital sensorineural hearing loss compared to controls?
Sevoflurane anesthesia prolongs QTc and QTVI intervals in children, but this effect is not exacerbated in those with congenital sensorineural hearing loss.
Answers are grounded in this paper and cite their sources.
Sevoflurane prolongs QT intervals similarly in children with or without congenital sensorineural hearing loss; leaves open arrhythmia risk and needs prospective validation.
Sevoflurane prolongs the QT interval (QTI). Patients with congenital sensorineural hearing loss (SNHL) often have a prolonged QTI. This study was to investigate the effects of sevoflurane on the QTI in SNHL and control children. Thirty patients with SNHL and 30 controls were studied. The corrected QT interval (QTc), interval from peak to end of T wave (Tp-e) and QT variability index (QTVI) were analysed. QTc and Tp-e were estimated by the average QTc and Tp-e measured beat-by-beat for 15 min. Heart rate power spectral analysis was performed. In both groups, QTc and QTVI increased during anaesthesia, but Tp-e did not change. There were no differences in QTc, QTVI, Tp-e, low- and high-frequency power between the two groups. In both groups, sevoflurane lengthened the QTc and QTVI intervals but not Tp-e.
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Kim et al. (2008) conducted an observational in Congenital sensorineural hearing loss (n=60). Sevoflurane vs. Control children was evaluated on Corrected QT interval (QTc), interval from peak to end of T wave (Tp-e) and QT variability index (QTVI). Sevoflurane lengthened the QTc and QTVI intervals similarly in both children with congenital sensorineural hearing loss and controls, with no differences between the groups.
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