Key result
Increasing sevoflurane concentrations prolonged the QTc interval from a baseline of 351.7 ms to a maximum of 397.8 ms, with a Ce50 of 2.5%.
Why the study?
Does sevoflurane concentration correlate with QTc prolongation in patients undergoing anesthesia?
Population
21 patients aged 20-50 yr
Design
Cohort
Follow-up
15 min
Authors
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Sevoflurane may warrant QTc monitoring during anesthesia; leaves open arrhythmia risk in vulnerable patients pending randomized confirmation.
Does sevoflurane concentration correlate with QTc prolongation in patients undergoing anesthesia?
Sevoflurane causes dose-dependent QTc prolongation at clinically relevant anesthetic concentrations.
Han et al. (2010) studied Anesthesia (n=21). Sevoflurane was evaluated on Corrected QT (QTc) interval prolongation. Increasing sevoflurane concentrations prolonged the QTc interval from a baseline of 351.7 ms to a maximum of 397.8 ms, with a Ce50 of 2.5%.
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