Key result
Spinal anaesthesia with levobupivacaine significantly prolonged the QTc maximum interval after skin closure compared to bupivacaine, which returned to baseline by the end of surgery.
Why the study?
Does spinal anaesthesia with levobupivacaine compared to bupivacaine affect QTc intervals in healthy pregnant women undergoing elective caesarean section?
RCT (n=60)
Double-blind
Randomized
Does spinal anaesthesia with levobupivacaine compared to bupivacaine affect QTc intervals in healthy pregnant women undergoing elective caesarean section?
Spinal anaesthesia with levobupivacaine leads to a more persistent prolongation of the QTc interval compared to bupivacaine during caesarean section.
Levobupivacaine causes more persistent QTc prolongation than bupivacaine after spinal anaesthesia for caesarean section; extends RCT data on local anaesthetics' repolarization effects.
The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivacaine group) or levobupivacaine (the levobupivacaine group). ECG recordings were performed prior to spinal anaesthesia at baseline (T1), 5 min. after spinal anaesthesia, but before uterine incision (T2), and after skin closure (T3). QT intervals were calculated and corrected with the patients' heart rate according to the Bazett formula. Compared with baseline values, mean maximum QTc intervals at T2 and T3 were significantly longer in the levobupivacaine group, but only at T2 in the bupivacaine group. In addition, compared with the bupivacaine group, the QTc maximum interval at T3 was significantly longer in the levobupivacaine group. At T2, the QTc maximum intervals were longer than baseline in both groups. By the end of the surgery, the prolongation of the QTc interval had disappeared in the bupivacaine group but not in the levobupivacaine group.
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Doğan et al. (2013) conducted an RCT in Healthy pregnant women scheduled for elective caesarean section (n=60). Levobupivacaine vs. Bupivacaine was evaluated on QTc interval changes during caesarean section. Spinal anaesthesia with levobupivacaine significantly prolonged the QTc maximum interval after skin closure compared to bupivacaine, which returned to baseline by the end of surgery.
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