Why the study?
Does alfentanil pretreatment reduce the haemodynamic response and QT interval prolongation following suxamethonium-facilitated intubation in children?
Population
68 healthy children (mean age 5.5 years) undergoing anaesthetic induction and endotracheal intubation
Comparison
Alfentanil 10, 25, or 50 micrograms/kg i.v… vs Saline i.v. administered 1 minute before…
Design
RCT, Randomized into 4 groups (17 children in each group), Double-blind
Follow-up
Immediate post-intubation period
Authors
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Supports alfentanil 25 μg/kg pretreatment in children; confirms dose-dependent attenuation of intubation responses in RCT.
Does alfentanil pretreatment reduce the haemodynamic response and QT interval prolongation following suxamethonium-facilitated intubation in children?
Alfentanil 25 micrograms/kg effectively attenuates the sympathoadrenal haemodynamic response and QT prolongation associated with suxamethonium-facilitated intubation in children.
Lindgren et al. (1991) studied this question.
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