February 2, 1996Science

Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K + Channel

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Population

Drosophila Shaker potassium channels expressed in mammalian cells

Design

Preclinical

Authors

TBThomas BaukrowitzKiel University GYGary YellenHarvard University

Discussion

Member takes

Implication

May guide Kv channel drug design; leaves open relevance to human cardiac electrophysiology.

Structured PICO

Population

Drosophila Shaker potassium channels expressed in mammalian cells

Intervention

Quaternary ammonium blockers

Outcome

Mechanism of use-dependent inhibition and exit rate of the last ion from the multi-ion poresurrogate

This basic science study elucidates the biophysical mechanism by which quaternary ammonium blockers induce use-dependent inhibition of voltage-activated potassium channels via C-type inactivation.

Cite This Study

Baukrowitz et al. (1996) studied this question.

synapsesocial.com/papers/6a90221ed27faa463b908fb4 https://doi.org/10.1126/science.271.5249.653

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Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K + Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K + Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider