What question did this study set out to answer?

To evaluate the efficacy of surgical resection and define indications for adjuvant and definitive radiation therapy in managing desmoid tumors.

January 1, 1999Journal of Clinical Oncology

Desmoid Tumor: Prognostic Factors and Outcome After Surgery, Radiation Therapy, or Combined Surgery and Radiation Therapy

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Authors

MBMatthew T. BalloThe University of Texas MD Anderson Cancer Center GZGunar K. ZagarsThe University of Texas MD Anderson Cancer Center APAlan PollackUniversity of Miami

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Implication

Retrospective study demonstrates that adjuvant radiation mitigates positive surgical margins in desmoid tumors, suggesting function-sparing resection combined with radiation is an effective strategy.

Key Points

To evaluate the efficacy of surgical resection and define indications for adjuvant and definitive radiation therapy in managing desmoid tumors.
Retrospective review of 189 consecutive patients with desmoid tumors.
Treatment arms included surgery alone (N=122), surgery with adjuvant radiation therapy (N=46), and definitive radiation therapy alone (N=21).
Patients were evaluated over a median follow-up of 9.4 years.
In the surgical cohort, 10-year relapse rates were 27% with negative margins (N=78) compared to 54% with positive margins (N=40; P = .003).
Ten-year actuarial relapse rates were 25% for combined resection and radiation therapy, and 24% for definitive radiation therapy alone.
Overall survival was 96% at 5 years, 92% at 10 years, and 87% at 15 years, with overall 10-year relapse rates reaching 33%.

Cite This Study

Ballo et al. (1999) studied this question.

synapsesocial.com/papers/6a9025a4e16d749e8fc9168d https://doi.org/10.1200/jco.1999.17.1.158

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Implication

Retrospective study demonstrates that adjuvant radiation mitigates positive surgical margins in desmoid tumors, suggesting function-sparing resection combined with radiation is an effective strategy.

Desmoid Tumor: Prognostic Factors and Outcome After Surgery, Radiation Therapy, or Combined Surgery and Radiation Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Desmoid Tumor: Prognostic Factors and Outcome After Surgery, Radiation Therapy, or Combined Surgery and Radiation Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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