Adenine was injected intraperitoneally to pregnant ICR-JCL mice on day 10 of gestation at a dosage of 200 or 250 mg/kg. The fetuses were examined externally on day 19 of gestation. Embryonic death, growth suppression and malformations such as encephalocele on forehead, cleft palate, cleft lip, limb defects and tail defects were induced. It is noteworthy that left-sided malformations were found in nine out of 11 fetuses with forelimb defects.
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Fujii et al. (1972) studied this question.
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