Why the study?
Does ribavirin eliminate foot-and-mouth disease virus in persistently infected cell cultures?
Does ribavirin eliminate foot-and-mouth disease virus in persistently infected cell cultures?
Ribavirin effectively clears foot-and-mouth disease virus from persistently infected cells in vitro, suggesting potential therapeutic application for carrier animals.
May inform antiviral testing in persistent infections; leaves open in vivo efficacy and clinical translation.
Ribavirin (1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide) eliminates foot-and-mouth disease virus from persistently infected cell cultures. The latter are 10-fold more sensitive to ribavirin than lytically infected cells. In treated cells no viral RNA or proteins could be detected by dot-blot hybridization to cDNA probes, virus and RNA infectivity assays, or immunofluorescence. A potential application of the drug for the treatment of animals carrying the virus is suggested.
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Torre et al. (1987) studied this question.
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