Key result
Vagus nerve stimulation has shown initial efficacy data and biological plausibility as a potential treatment for patients with inflammatory bowel disease.
Why the study?
Many patients with inflammatory bowel disease lose response to treatments or experience side effects, making the brain-gut axis and vagus nerve stimulation an emerging therapeutic perspective.
Does vagus nerve stimulation improve outcomes in patients with inflammatory bowel disease?
Does vagus nerve stimulation improve outcomes in patients with inflammatory bowel disease?
This narrative review highlights the biological plausibility and early clinical data supporting vagus nerve stimulation as a potential therapy for inflammatory bowel disease.
Vagus nerve stimulation (VNS) is an accepted therapy for the treatment of refractory forms of epilepsy and depression. The brain-gut axis is increasingly being studied as a possible etiological factor of chronic inflammatory diseases, including inflammatory bowel diseases (IBD). A significant percentage of IBD patients lose response to treatments or experience side effects. In this perspective, VNS has shown the first efficacy data. The aim of this narrative review is to underline the biological plausibility of the use of VNS in patients affected by IBD, collect all clinical data in the literature, and hypothesize a target IBD population on which to focus the next clinical study.
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Fornaro et al. (2022) conducted a review in Inflammatory Bowel Disease (IBD). Vagus nerve stimulation (VNS) was evaluated. Vagus nerve stimulation has shown initial efficacy data and biological plausibility as a potential treatment for patients with inflammatory bowel disease.
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