Key result
Neuromodulation and vagus nerve stimulation present a promising theoretical approach for treating recalcitrant inflammatory skin diseases by restoring autonomic balance and reducing pro-inflammatory cytokines.
This commentary proposes that neuromodulation via vagus nerve stimulation could serve as a novel therapeutic avenue for severe inflammatory skin diseases, based on its efficacy in other chronic inflammatory conditions.
Hypothesis-generating for neuromodulation in recalcitrant dermatoses; leaves open clinical translation pending controlled trials.
Inflammatory skin diseases are difficult to treat because of a lack of available treatment options for severe disease. However, recent advances have shown that vagus nerve stimulation can be used to decrease inflammation and reduce disease severity in rheumatoid arthritis and inflammatory bowel disease. Changes in cytokine profiles observed in these studies are similar to those seen with use of biologics in inflammatory skin disease, suggesting that they act along similar pathways to disrupt chronic inflammation and treat inflammatory disease. This commentary explores the existing evidence demonstrating the efficacy of neuromodulation in inflammatory disease, and outlines reasons why these findings could translate to the dermatology setting to treat inflammatory skin disease.
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Yang et al. (2018) conducted a review in Inflammatory skin disease. Neuromodulation (Vagus nerve stimulation) was evaluated. Neuromodulation and vagus nerve stimulation present a promising theoretical approach for treating recalcitrant inflammatory skin diseases by restoring autonomic balance and reducing pro-inflammatory cytokines.
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