Use of antioxidant in the attempt recovery of insulin receptors in salivary glands of spontaneously diabetic mice

The incidence of diabetes mellitus has increased over the years. Currently 4.6 million people die due to this disease. Approximately 10% of cases are type I, affecting 90% of cases in childhood, demonstrating the epidemiologic importance of diabetes. Diabetes affects different tissues, including the salivary glands which are similar in morphological characteristics to the pancreas. This hyperglycemic condition is related also to production of reactive oxygen species (ROS), which increase the damage tissue. Thus, some studies have used antioxidants, including N-acetylcysteine (NAC) in an attempt to modulate these processes by avoiding tissue damage. However, the NAC appears to promote a infiltration of CD4 and CD8 lymphocytes, intensifying the hyperglycemic condition. To avoid this it is necessary the combination of antibodies specific to obtain the antioxidant action and prevent the disease progression. In addition to this, the moderate physical exercise can also exert influence in cell homeostasis, regulating the oxidative damage and ARTIGO DE REVISAO