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July 19, 1975BMJOpen Access

Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.

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Why the study?

Are HL-A 8 and W 15 antigens associated with juvenile-onset diabetes mellitus?

Population

150 patients with juvenile-onset diabetes mellitus, 68 patients with older-onset diabetes, 300 healthy…

Design

Case-control

Authors

ACA G CudworthDoncaster CouncilJWJ. C. WoodrowHarvard University

Discussion

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Implication

May indicate genetic susceptibility in juvenile-onset diabetes; leaves open clinical utility pending prospective validation.

Structured PICO

Are HL-A 8 and W 15 antigens associated with juvenile-onset diabetes mellitus?

P
Population
150 patients with juvenile-onset diabetes mellitus (age at onset ≤ 30 years), 68 patients with older-onset diabetes (age > 30 years), 300 healthy controls, and 17 families with two or more diabetic siblings.
C
Comparator
Healthy controls and older-onset diabetics
O
Outcome
Frequency of HL-A 8 and W 15 antigens and zygotic assortment of HL-A haplotypessurrogate

The study demonstrates a significant association between juvenile-onset diabetes and HL-A 8 and W 15 antigens, suggesting the presence of a closely linked diabetogenic gene.

Cite This Study

Cudworth et al. (1975) studied this question.

synapsesocial.com/papers/6a902bc473c1f5e62dc91d8dhttps://doi.org/10.1136/bmj.3.5976.133
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM1953 · 3,806 citations
  2. 2Genetics and the Epidemiology of Chronic Diseases.1965 · 22 citations
  3. 3HL-A System and Diabetes Mellitus1975 · 156 citations