An evacuation system for the production of extreme hypoxia is described. With this system survival curves using asynchronous Chinese hamster cells for extremely hypoxic and aerobic conditions have a common extrapolation number and a dose-modifying factor of 3.0-3.1. When synchronized hypoxic cells are irradiated during the most resistant phase of the age-response cycle and kept hypoxic between doses, no recovery from sublethal damage is observed.
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Koch et al. (1971) studied this question.