What question did this study set out to answer?

To evaluate the impact of early intravenous verapamil administration on cardiac enzyme release in patients experiencing acute myocardial infarction.

April 2, 1983BMJOpen Access

Effect of verapamil on enzyme release after early intravenous administration in acute myocardial infarction: double blind randomised trial.

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Why the study?

Does early intravenous verapamil affect enzyme release in acute myocardial infarction?

Population

acute myocardial infarction

Design

RCT, randomised, double blind

Authors

LTLeif ThuesenInterventional Cardiology JJJ JørgensenCincinnati Children's Hospital Medical Center HKH J KvistgaardAarhus Municipality

Discussion

Member takes

Implication

Early IV verapamil does not reduce enzyme release in AMI; challenges experimental infarct-size data and leaves timing or dosing questions open.

Key Points

To evaluate the impact of early intravenous verapamil administration on cardiac enzyme release in patients experiencing acute myocardial infarction.
Double-blind randomized controlled trial comparing early intravenous verapamil against control.
Serial measurement of serum cardiac enzyme release following administration to assess infarct size and myocardial damage.
Quantitative event rates, effect sizes, and enzyme curves are not reported in the available summary text.
Trial design focuses on assessing whether early calcium channel blockade modifies the kinetics and extent of myocardial enzyme release.

Structured PICO

Does early intravenous verapamil affect enzyme release in acute myocardial infarction?

Population

acute myocardial infarction

Intervention

early intravenous verapamil

Outcome

enzyme releasesurrogate

Cite This Study

Thuesen et al. (1983) studied this question.

synapsesocial.com/papers/6a902e63e8d327d500341a38 https://doi.org/10.1136/bmj.286.6371.1107

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Implication

Early IV verapamil does not reduce enzyme release in AMI; challenges experimental infarct-size data and leaves timing or dosing questions open.

Effect of verapamil on enzyme release after early intravenous administration in acute myocardial infarction: double blind randomised trial.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of verapamil on enzyme release after early intravenous administration in acute myocardial infarction: double blind randomised trial.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider