Influence of Capillary Permeability on Flow of Tissue Fluid Into Gingival Pockets

The flow of tissue fluid from subepithelial coinpartnients into clinically healthy gingival pockets has been demonstrated in dogs (Brill h Krasse, 1958) and in man (Brill h Bjorn, 1959). The flow of this fluid increases markedly, when gingival structures are stimulated by tooth brushing (Brill h Krasse, 1959), chewing (Brill, 1959), and in chronic gingivitis (Brill h Bjorn, 1959). This effect might be due to changes either in the vascular bed, the connective tissue or the epithelial barrier of the gingival pockets, but it is also possible that changes responsible for the effect occur in all three tissues concurrently. The present study was designed to elucidate the effect of changes in capillary permeability on the flow of tissue fluid into gingival pockets. The circulatory system of the marginal gingivae comprises a terminal vascular bed including capillaries. (Parma, 1939, Pelzer, 1940, Franke, 1956). The perviousness of capillary walls is generally stated to be variable. (Krogh, 1929). It is well known that histamine increases the permeability of capillaries. A similar effect is observed after mechanical stiinulation (Lewis, 1927), and in initial stages of inflaniniation caused by mechanical niicrotrauniata (Zweifach, 1953). The result is a copious outflow of fluid and protein material.