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A simple solution to the age-old problem of the Heck reaction of cheap but unreactive chloro- and bromoarenes [for example, reaction (1)] has been found in the catalyst [Pd(CH3CN)2Cl2]⋅6 Ph4PCl in the presence of N,N-dimethylglycine as additive. The reaction then proceeds with exceptionally high efficiency.
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Reetz et al. (1998) studied this question.
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