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The historical origins of chemical topology are highlighted and seven open problems in the discipline are defined. The current state of experimental work towards their solutions is reviewed. Open problems discussed include size and tightness limits on molecular knots, synthesis of knots more complex than the trefoil, measurement of the enantiomerization barrier of a topological rubber glove, and syntheses of a polyethylene trefoil knot, a stable open knot with stoppers, and a molecular Whitehead link.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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Edward E. Fenlon (2008) studied this question.
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