Tying up the loose ends: Cyclization of a linear hexapeptide made from alternating valine and α-aminodeoxycholanic acid units yielded two macrolactams: cyclo(valine-3-α-aminodeoxycholic acid amide)3 and cyclo(valine-3-α-aminodeoxycholic acid amide)6, the product of a cyclodimerization (see structure). X-Ray diffraction studies confirmed that the latter compound has the structure of a trefoil knot.
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Feigel et al. (2006) studied this question.
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