Key result
Carrying one Gly389 ADRB1 allele was associated with an increased risk for obesity in Mexican children (OR 1.40; 95% CI 1.03-1.90; P=0.03).
Why the study?
Are Arg389Gly ADRB1 and Trp64Arg ADRB3 polymorphisms associated with obesity in Mexican children?
Cross-Sectional (n=1,046)
Yes
Are Arg389Gly ADRB1 and Trp64Arg ADRB3 polymorphisms associated with obesity in Mexican children?
Odds Ratio: 1.4 (95% CI 1.03–1.9)
p-value: p=0.03
The Arg389Gly ADRB1 polymorphism, but not the Trp64Arg ADRB3 polymorphism, is associated with an increased risk of obesity in Mexican children.
Should not change pediatric obesity management; hypothesis-generating for ADRB1 variants and requires prospective replication.
This research was designed to analyze the possible associations of Arg389Gly ADRB1 and Trp64Arg ADRB3 polymorphisms in children with obesity. A cross-sectional study included 1,046 school-age Mexican participants (6-12 years old) from the cities of San Luis Potosí and León. Children were classified as non-obese or obese according to their body mass index (BMI) percentile; obese children had a BMI≥95th percentile for sex and age. Biochemical data were collected. Polymorphisms were detected using TaqMan qPCR assay. A logistic regression analysis was used to calculate the risk of obesity based on genotypes. Differences were found between groups where obese children had a significant increase in systolic and diastolic blood pressure, fasting plasma glucose, insulin, HOMAIR, LDL-cholesterol, triglycerides, and lower HDL-cholesterol compared with the normal weight group (P < 0.05).The distribution of allele frequency in the population was Arg = 87.4 and Gly = 12.6 (Hardy Weinberg equilibrium c2 = 3.16 , P = 0.07 ); Trp = 81.5 and Arg = 18.5 (Hardy Weinberg equilibrium c2 = 2.2, P = 0.14 ) for ADRB1 and ADRB3, respectively. Even though no different frequencies of Arg389Gly polymorphism between groups were found (P = 0.08), children carriers of one Gly389 ADRB1 allele had a risk for obesity of OR = 1.40 (95%CI, 1.03–1.90, P = 0.03) after adjustment for age and gender. No other association was found for Trp64Arg ADRB3 polymorphism. Only the Arg389Gly ADRB1 polymorphism was associated with risk for obesity in Mexican children.
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Celia et al. (2017) conducted a cross-sectional in obesity (n=1,046). Gly389 ADRB1 allele vs. Non-carriers was evaluated on risk of obesity (OR 1.40, 95% CI 1.03-1.90, p=0.03). Carrying one Gly389 ADRB1 allele was associated with an increased risk for obesity in Mexican children (OR 1.40; 95% CI 1.03-1.90; P=0.03).
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