Why the study?
ADRB3 gene polymorphism association with metabolic disturbances had never been studied before in the ethnic Kyrgyz population.
Is the Trp64Arg polymorphism of the ADRB3 gene associated with metabolic syndrome components in an ethnic Kyrgyz population?
Cross-Sectional (n=213)
Is the Trp64Arg polymorphism of the ADRB3 gene associated with metabolic syndrome components in an ethnic Kyrgyz population?
Odds Ratio: 3.159 (95% CI 1.789–5.577)
Absolute Event Rate: 55.2% vs 29%
p-value: p=<0.00009
The Arg64 allele of the ADRB3 gene is associated with an increased risk of obesity and abdominal obesity in the ethnic Kyrgyz population.
BackgroundsB3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population.AimTo study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.Materials and methods213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH).ResultsTrp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity.ConclusionArg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.
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Kerimkulova et al. (2011) conducted a cross-sectional in Metabolic syndrome components (obesity, abdominal obesity, hypertension) (n=213). Arg64 allele of the ADRB3 gene (Trp64Arg or Arg64Arg genotype) vs. Trp64Trp genotype was evaluated on Obesity (OR 3.159, 95% CI 1.789-5.577, p=<0.00009).
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