Key result
Despite numerous studies on the association of polymorphic markers of candidate genes (AGT, ACE, ADRB2) with congestive heart failure, no consensus on their impact has been achieved.
The review highlights the lack of consensus regarding the role of genetic polymorphisms in congestive heart failure and emphasizes the need for further research considering ethnic and geographical variability.
The article reviews studies of gene polymorphisms effects on the phenotype and the prognostic value of the genotype determination in patients with congestive heart failure. The results of studies analyzing the impact of angiotensinogen, angiotensin-converting enzyme, β2-adrenoreceptor genes polymorphism on the development of hypertension, myocardial and carotid arteries damage, and congestive heart failure prognosis are surveyed. However, despite the large number of studies addressing the association of polymorphic markers of candidate genes and phenotype, no consensus on the impact of candidate genes on the major systems involved in the pathogenesis of congestive heart failure has been achieved so far. Due to gene distribution variability in different populations, the studies of ethnic and geographical association of candidate genes with congestive heart failure development, as well as studies of phenotypic markers of the disease, are still relevant.
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Bulashova et al. (2013) conducted a review in Congestive heart failure. Genetic polymorphisms (AGT, ACE, ADRB2) was evaluated. Despite numerous studies on the association of polymorphic markers of candidate genes (AGT, ACE, ADRB2) with congestive heart failure, no consensus on their impact has been achieved.
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