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January 28, 1991FEBS LettersOpen Access

Cloning and functional expression of a TEA‐sensitive A‐type potassium channel from rat brain

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Population

Xenopus laevis oocytes injected with rat brain cDNA (Raw3) cRNA

Comparison

Raw3 cRNA injection vs RCK4 (previously cloned rat A-type K+ channel)

Design

Preclinical

Authors

KSKlaus-Hasso SchröterUniversity of GroningenJRJ. P. RuppersbergGoogle (United States)FWFrank WunderDrug Discovery Laboratory (Norway)

Discussion

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Overview

Identifies Raw3 as a distinct A-type K+ channel; leaves open its roles in excitability and any cardiac relevance.

Structured PICO

P
Population
Xenopus laevis oocytes injected with rat brain cDNA (Raw3) cRNA
I
Intervention
Raw3 cRNA injection
C
Comparator
RCK4 (previously cloned rat A-type K+ channel)
O
Outcome
Formation and electrophysiological properties of K+ channelssurrogate

The study characterizes a novel rat brain A-type potassium channel (Raw3) with distinct electrophysiological properties compared to previously known channels.

Cite This Study

Schröter et al. (1991) studied this question.

synapsesocial.com/papers/6a9032da3dd9003d79c90fbdhttps://doi.org/10.1016/0014-5793(91)80119-n
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cells1989 · 188 citations
  2. 2DNA sequencing with chain-terminating inhibitors1977 · 69,496 citations
  3. 3Functional messenger RNAs are produced by SP6<i>in vitro</i>transcription of cloned cDNAs1984 · 1,550 citations