Why the study?
Are the angiotensinogen M235T and ACE I/D genetic variants related to the severity of hypertension in Caucasian patients with essential hypertension?
Population
321 Caucasian patients with established essential hypertension, excluding those with secondary hypertension.
Comparison
Angiotensinogen M235T and angiotensin-converting… vs Comparison between different genotypic groups
Design
Cross-sectional
Authors
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No association with ambulatory BP or LV dimensions; leaves open utility of these genotypes as hypertension severity markers.
Are the angiotensinogen M235T and ACE I/D genetic variants related to the severity of hypertension in Caucasian patients with essential hypertension?
Angiotensinogen M235T and ACE I/D genetic variants do not appear to be clinically useful markers for determining the severity of essential hypertension in Caucasian patients.
Beige et al. (1997) studied this question.
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