Most of the LDL receptor family members recognize apolipoprotein E. The structures of the VLDL receptor, and recently identified apolipoprotein E receptor 2, closely resemble the LDL receptor. Recent studies have demonstrated that the VLDL receptor is responsible for the reproduction of premammalian species by mediating oogenesis. Despite the importance of the VLDL receptor in premammalian species, the biological role of the mammalian VLDL receptor is still unclear. Apolipoprotein E receptor 2 is structurally most closely related to the LDL receptor and expressed predominantly in brain. This newly identified receptor may play a role in the uptake of cholesterol in the central nervous system.
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Yamamoto et al. (1996) studied this question.