Quantitation of hepatitis C virus RNA by competitive polymerase chain reaction

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Why the study?

Does alpha-interferon reduce serum HCV RNA levels in patients with hepatitis C?

Population

5 patients with hepatitis C virus infection

Design

Case_series

Authors

Discussion

Alpha-interferon was associated with HCV RNA decline in this case; case report leaves open efficacy in larger trials.

Does alpha-interferon reduce serum HCV RNA levels in patients with hepatitis C?

Population

5 patients with hepatitis C virus infection (2 whose serum was used to infect chimpanzees, 3 treated with alpha-interferon)

Intervention

Alpha-interferon (in 3 patients)

Outcome

Quantitation of serum HCV RNAsurrogate

Competitive PCR allows for accurate quantitation of serum HCV RNA, which correlates with response to alpha-interferon treatment.

Kaneko et al. (1992) studied this question.

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