Key result
Ivabradine monotherapy successfully restored sinus rhythm in 100% (2 of 2) of premature infants with accelerated idioventricular rhythm after other antiarrhythmic agents had failed.
Why the study?
Ivabradine has been used for focal atrial and junctional ectopic tachycardias in children, but its use for accelerated idioventricular rhythm remains limited.
Does ivabradine restore sinus rhythm in premature infants with accelerated idioventricular rhythm?
Case Report (n=2)
Does ivabradine restore sinus rhythm in premature infants with accelerated idioventricular rhythm?
Ivabradine may be a promising and hemodynamically stable antiarrhythmic option for treating accelerated idioventricular rhythm in premature infants.
Answers are grounded in this paper and cite their sources.
May be considered for refractory AIVR in premature infants; leaves open the need for prospective trials to confirm safety and efficacy.
INTRODUCTION: Ivabradine has been recently introduced to treat focal atrial tachycardia and junctional ectopic tachycardia in children. Its use for treating ventricular tachyarrhythmias, specifically accelerated idioventricular rhythm (AIVR), remains limited. METHODS AND RESULTS: We report two cases of premature infants with AIVR successfully treated with ivabradine as monotherapy after other antiarrhythmic agents had failed. The first infant had a structurally normal heart and the second infant a truncus arteriosus. In both patients, sinus rhythm was restored with ivabradine. Side effects only consisted of brief, hemodynamically insignificant episodes of bradycardia. CONCLUSIONS: Ivabradine represents a promising antiarrhythmic agent for treating AIVR in preterm infants. Its ability to maintain hemodynamic stability in this age group makes ivabradine an attractive option for managing AIVR, especially in the postoperative setting. Further research is warranted to explore the safety, dosage, and mechanistic action of ivabradine for AIVR in the premature, neonatal infant patient population.
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Misier et al. (2025) conducted a case report in Accelerated idioventricular rhythm (AIVR) (n=2). Ivabradine was evaluated on Restoration of sinus rhythm. Ivabradine monotherapy successfully restored sinus rhythm in 100% (2 of 2) of premature infants with accelerated idioventricular rhythm after other antiarrhythmic agents had failed.
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