Key result
The abstract describes the rationale and objective of a retrospective study evaluating the association between thiazide diuretics and osteoporotic fractures in older women, but reports no results.
Why the study?
Does regular use of thiazide diuretics as antihypertensive therapeutics increase the risk of osteoporotic fractures in female patients, aged over 70 years?
Observational
Does regular use of thiazide diuretics as antihypertensive therapeutics increase the risk of osteoporotic fractures in female patients, aged over 70 years?
No results reported, precluding practice change; leaves open thiazide-fracture association in older women.
An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study (Am J Med. 2016 Dec; 129(12):1299-1306). However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs , as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i.e. furosemide and similar drugs . The purpose of this retrospective study is to attempt to clarify whether regular use of thiazide diuretics as antihypertensive therapeutics is associated with a significantly increased risk of osteoporotic fractures in female patients, aged over 70 years.
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Vecchis et al. (2017) conducted an observational in Hypertension. Thiazide diuretics was evaluated on Osteoporotic fractures. The abstract describes the rationale and objective of a retrospective study evaluating the association between thiazide diuretics and osteoporotic fractures in older women, but reports no results.
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