Key result
Administration of recombinant mouse IL-5 reduced infarct size and increased ejection fraction and angiogenesis in mice post-myocardial infarction by promoting eosinophil accumulation.
Why the study?
It remains unknown whether interleukin-5 plays a role in heart repair after myocardial infarction.
Does recombinant IL-5 improve cardiac function and reduce infarct size in a mouse model of myocardial infarction?
Population
Wild-type C57BL/6 mice with permanent LAD coronary artery ligation-induced MI
Comparison
Recombinant mouse IL-5 vs control or eosinophil depletion
Design
Preclinical animal and in vitro mechanistic study
Authors
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IL-5/EOS axis may aid murine post-MI repair; leaves open human therapeutic relevance.
Does recombinant IL-5 improve cardiac function and reduce infarct size in a mouse model of myocardial infarction?
IL-5 facilitates recovery of cardiac dysfunction post-MI by promoting eosinophil accumulation and CD206+ macrophage polarization.
Xu et al. (2021) studied Myocardial infarction. Recombinant mouse IL-5 was evaluated on Infarct size, ejection fraction, and angiogenesis. Administration of recombinant mouse IL-5 reduced infarct size and increased ejection fraction and angiogenesis in mice post-myocardial infarction by promoting eosinophil accumulation.
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