Key result
Phylogenetic analysis of the 1A and 3D gene regions of Coxsackievirus B3 strain CC revealed a close evolutionary relationship with the Nancy strain and evidence of recombination among strains.
Sequencing of the CVB3-CC strain reveals a close evolutionary relationship with the CVB3 Nancy strain and evidence of recombination, providing genetic insights into a common cause of viral myocarditis.
Animal data on CVB3 recombination; extends phylogenetic insights but leaves open human myocarditis applications.
Coxsackievirus B3 (CVB3) was thought to be the most common causative agent of life-threatening viral myocarditis. Coxsackievirus B3 strain CC (CVB3-CC) was isolated in China; however, no sequence data are available. The 1A and 3D regions of CVB3-CC were sequenced and phylogenetic analysis was done with reference to ten other CVB3 strains and all 36 prototype strains of human enterovirus B (HEV-B). Sequence analysis showed that the 1A gene region of CVB3-CC consisted of 207 nucleotides, encoding 69 amino acids; and the 3D gene region was comprised of 1386 nucleotides, encoding 462 amino acids. Variation analysis showed that the 3D gene of CVB3 strain CC varied the least among the two regions. Phylogenetic tree analysis of the 1A and 3D regions indicated that CVB3-CC clustered together with CVB3 Nancy strain suggesting that there may be a close evolutionary relationship between the two strains. Incongruity was observed between the non-structural protein gene and the structural protein gene trees, according to the topological structure, indicating that recombination was occurred among these strains.
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Liu et al. (2008) studied Viral myocarditis. Phylogenetic analysis of the 1A and 3D gene regions of Coxsackievirus B3 strain CC revealed a close evolutionary relationship with the Nancy strain and evidence of recombination among strains.
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