Key result
Children with ADHD and their siblings exhibited higher levels of pervasive developmental disorder symptoms than healthy controls, with a significant sibling correlation (r=0.28) that was largely independent of ADHD severity.
Cross-Sectional (n=659)
Yes
Effect estimate: r=0.28
p-value: p=<0.001
Children with ADHD and their siblings have higher levels of PDD symptoms than healthy controls, and the familiality of subtle PDD symptoms appears largely independent of ADHD familiality.
Supports shared familial factors linking ADHD and PDD symptoms; leaves open clinical utility pending longitudinal studies.
OBJECTIVES: To determine the relationship between physical activity and cognition, specifically executive function, and the possible mediating role of factors such as cardiovascular disease (CVD) and CVD risk factors, chronic pain, and depressive symptoms. DESIGN: Cross-sectional study. SETTING: Population-based study of individuals aged 70 and older in the Boston area. PARTICIPANTS: Older community-dwelling adults (n=544; mean age 78, 62% female). MEASUREMENTS: Presence of heart disease (self-reported physician diagnosed), pain, and depressive symptomatology were assessed using interviewer-administered questions. Blood pressure was measured. Engagement in physical activity was determined using the Physical Activity Scale for the Elderly (PASE). Cognitive function was measured using a battery of neuropsychological tests. RESULTS: The older adults who engaged in more physical activity had significantly better performance on all cognitive tests, except for Letter Fluency and the memory test of delayed recall, after adjusting for age, sex, education, and total number of medications. With further adjustment for CVD and CVD risk factors (heart disease, diabetes mellitus, stroke, and hypertension), pain, and depressive symptoms, PASE score remained significantly associated with executive function tests. CONCLUSION: Even after multivariate adjustment, neuropsychological tests that were executive in nature were positively associated with physical activity participation in this cohort of older community-dwelling adults. In contrast, delayed recall of episodic memory was not associated with physical activity, supporting the idea that the relationship with executive function represents a specific biologically determined relationship.
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Eggermont et al. (2009) conducted a cross-sectional in Attention-Deficit/Hyperactivity Disorder (ADHD) (n=659). ADHD vs. Healthy controls was evaluated on Sibling correlation of PDD symptoms (CSBQ total score) (r=0.28, p=<0.001). Children with ADHD and their siblings exhibited higher levels of pervasive developmental disorder symptoms than healthy controls, with a significant sibling correlation (r=0.28) that was largely independent of ADHD severity.
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