What question did this study set out to answer?

To assess the prevalence and co-expression patterns of CLDN18.2, HER2, and PD-L1 in global gastric and gastroesophageal junction cancer samples.

October 1, 2018Annals of OncologyOpen Access

Prevalence of CLDN18.2, HER2 and PD-L1 in gastric cancer samples

View Full Paper

Ask AI

Bookmark

To assess the prevalence and co-expression patterns of CLDN18.2, HER2, and PD-L1 in global gastric and gastroesophageal junction cancer samples.
Evaluated 298 formalin-fixed paraffin-embedded gastric and gastroesophageal junction tissue samples from North America (n = 100), Asia (n = 100), and Europe (n = 98).
Stained samples via automated immunohistochemistry for CLDN18.2, PD-L1, and HER2, with HER2 gene amplification confirmed by chromogenic in situ hybridization.
High CLDN18.2 expression occurred in 30% (n = 86/286) of evaluable samples, with regional rates of 24% (n = 22/92) in Asia and 34% (n = 33/97) in North America.
HER2 positivity was detected in 10% (n = 29/291) and PD-L1 positivity in 37% (n = 107/289) of evaluable tumor specimens.
Among CLDN18.2-high cases evaluable for HER2, overlap occurred in only 12% (n = 10/83) of samples.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Cross-sectional analysis reveals high CLDN18.2 expression with minimal HER2 overlap in gastric cancer, highlighting its potential as an independent therapeutic target.

Cite This Study

Moran et al. (2018) studied this question.

synapsesocial.com/papers/6a903fa8a9ec819f9b2da1f5 https://doi.org/10.1093/annonc/mdy269.101

View Full Paper

Ask AI

Bookmark

Implication

Cross-sectional analysis reveals high CLDN18.2 expression with minimal HER2 overlap in gastric cancer, highlighting its potential as an independent therapeutic target.

Prevalence of CLDN18.2, HER2 and PD-L1 in gastric cancer samples

Key Points

Discussion

Implication

Cite This Study

Prevalence of CLDN18.2, HER2 and PD-L1 in gastric cancer samples

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider