Serrated polyposis and the less common polyposis syndromes

While familial adenomatous polyposis is one of the most widely recognized adenomatous polyposis syndromes, there are several less common polyposis syndromes that healthcare providers may encounter in practice. We review the epidemiology, pathogenesis, cancer risk and clinical management for serrated polyposis syndrome, MUTYH -associated polyposis, colonic oligopolyposis of unknown etiology, in addition to emerging polyposis syndromes such as polymerase proofreading-associated polyposis, NTHL1 -associated polyposis, MSH3 -associated polyposis, and GREM1 -associated polyposis.