Key result
Multi-scale computational models of subcellular calcium handling provide critical insights into the structure-function relationships of excitation-contraction coupling in normal and diseased hearts.
Design
Review
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Informs mechanistic cardiac research; leaves open clinical translation pending prospective validation.
Multi-scale computational modeling provides critical insights into the spatio-temporal dynamics of subcellular calcium handling and its disruption in cardiac pathologies.
Maleckar et al. (2017) conducted a review in Cardiac calcium dynamics and excitation-contraction coupling. Computational modeling of subcellular calcium handling was evaluated. Multi-scale computational models of subcellular calcium handling provide critical insights into the structure-function relationships of excitation-contraction coupling in normal and diseased hearts.
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