Preclinical study demonstrates altered respiratory mucosal immunity from obese gut microbiota in a gnotobiotic pig model, highlighting limitations of murine systems for human immune translation.
The diversity of gut microbiome of obese people differs markedly from that of lean healthy individuals which, in turn, influences the severity of inflammatory diseases because of differential maturation of immune system. The mouse model provides crucial insights into the mechanism(s) regulating the immune systems mediated by the gut microbiota but its applicability to humans is questionable because immune cells in mice are poorly activated in microbiota humanized mice. Several important strains of Bifidobacterium , Lactobacillus , and Clostridium fails to colonize the murine gut.
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Renu et al. (2022) studied this question.
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