Urokinase excretion rates are significantly altered in various disease states, including elevation after myocardial infarction and depression in congestive heart failure, suggesting changes in the plasma fibrinolytic system.
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Altered urokinase excretion may reflect fibrinolytic shifts in MI and HF; hypothesis-generating and requires prospective studies before clinical relevance.
Smyrniotis et al. (1959) studied this question.
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