What question did this study set out to answer?

To assess the hemodynamic and angiographic effects of pulmonary artery bolus urokinase infusion in acute pulmonary thromboembolism.

January 1, 1974

Hemodynamic effects of bolus infusion of urokinase in pulmonary thromboembolism.

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To assess the hemodynamic and angiographic effects of pulmonary artery bolus urokinase infusion in acute pulmonary thromboembolism.
Evaluated hemodynamic changes in 13 patients presenting with acute pulmonary thromboembolism.
Administered bolus injections of urokinase directly into the pulmonary artery in 9 patients, categorized by the presence or absence of underlying cardiopulmonary disease.
Treated a comparison group of 4 patients with heparin alone to observe immediate hemodynamic responses.
In urokinase-treated patients without prior cardiopulmonary disease (n=4), rapid and sustained decreases occurred in both pulmonary arterial pressure and total pulmonary resistance.
Patients with preexisting cardiovascular disease (n=5) experienced less pronounced reductions in pulmonary pressures and resistance, while angiographic improvements directly mirrored hemodynamic recovery.
Patients treated with heparin alone (n=4) showed no immediate reduction in pulmonary arterial pressure or total pulmonary resistance.

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Implication

Comparative study reveals bolus urokinase rapidly reduces pulmonary artery pressure in acute pulmonary thromboembolism, highlighting its therapeutic efficacy compared with heparin alone.

Cite This Study

Dickie et al. (1974) studied this question.

synapsesocial.com/papers/6a6f21d235aa2c282ce0894b https://doi.org/10.1164/arrd.1974.109.1.48

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Implication

Comparative study reveals bolus urokinase rapidly reduces pulmonary artery pressure in acute pulmonary thromboembolism, highlighting its therapeutic efficacy compared with heparin alone.

Hemodynamic effects of bolus infusion of urokinase in pulmonary thromboembolism.

Key Points

Discussion

Implication

Cite This Study

Hemodynamic effects of bolus infusion of urokinase in pulmonary thromboembolism.

Key Points

Discussion

Implication

Cite This Study

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