Key result
Streptokinase therapy in acute major pulmonary embolism led to angiographic improvement in 75% of evaluated patients, compared to 0% in those treated with heparin.
Why the study?
Does streptokinase improve clinical and angiographic outcomes in patients with acute major pulmonary embolism?
Population
18 patients with acute major pulmonary embolism
Comparison
Streptokinase infused by a catheter or given… vs Heparin treatment (observed in 3 patients)
Design
Case_series
Follow-up
24 to 48 hours
Authors
Loading...
Streptokinase may accelerate resolution in major PE; leaves open superiority over heparin pending randomized trials.
Observational (n=21)
Does streptokinase improve clinical and angiographic outcomes in patients with acute major pulmonary embolism?
Absolute Event Rate: 75% vs 0%
Streptokinase therapy hastens early angiographic and clinical resolution in acute major pulmonary embolism, particularly when administered shortly after a single embolic episode.
Hirsh et al. (1968) conducted an observational in Acute major pulmonary embolism (n=21). Streptokinase vs. Heparin was evaluated on Angiographic improvement. Streptokinase therapy in acute major pulmonary embolism led to angiographic improvement in 75% of evaluated patients, compared to 0% in those treated with heparin.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: